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💊 Free Pet Medication Calculator

Safe OTC Medication Doses for Dogs & Cats

Last updated: June 2026

Get weight-based dosage estimates for common over-the-counter medications.

Based on veterinary guidelines — always confirm with your vet before giving any medication.

✅ Vet-Referenced·✅ Weight-Based Dosing·✅ Tablet Count Included·✅ Free

⚠️ This tool provides ESTIMATES ONLY based on published veterinary references. It is NOT a substitute for veterinary advice. Always consult your vet before giving any medication to your pet. Never give medications to cats without explicit vet guidance — many human medications are toxic to cats.

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Frequently Asked Questions

Safe Over-the-Counter Medications for Dogs and Cats

Several common human over-the-counter (OTC) medications can be safely used for dogs and cats at the correct weight-based dosage. However, dosing for pets is very different from human dosing — even a small overdose can cause serious harm. Our calculator above provides safe dosages based on your pet's weight, but always confirm with your veterinarian before administering any medication.

The most commonly used OTC medications for pets include:

  • Diphenhydramine (Benadryl): For allergies, itching, and mild sedation. Dose: 1 mg per pound of body weight, every 8–12 hours.
  • Famotidine (Pepcid AC): For stomach acid and vomiting. Dose: 0.25–0.5 mg per pound, every 12–24 hours.
  • Melatonin: For anxiety and sleep regulation. Dose: 3–6 mg per dose for dogs, 1–3 mg for cats.
  • Omeprazole (Prilosec): For severe acid reflux. Dose: 0.5–1 mg per kg, once daily.
  • Pseudoephedrine: NEVER give to pets — highly toxic to dogs and cats.

Medications That Are Toxic to Pets

Many common human medications are extremely dangerous — even fatal — to dogs and cats. Never give your pet:

  • Acetaminophen (Tylenol): Fatal to cats, causes liver damage in dogs
  • Ibuprofen (Advil, Motrin): Causes stomach ulcers and kidney failure in both species
  • Naproxen (Aleve): Extremely toxic — even a single pill can cause fatal kidney failure
  • Aspirin: Can be used for dogs only under vet supervision, but never for cats without specific veterinary guidance
  • Decongestants (pseudoephedrine, phenylephrine): Cause dangerous heart rate increases

If your pet accidentally ingests any human medication, call your vet or the Pet Poison Helpline (855-764-7661) immediately. Emergency treatment can cost $300–$1,500 — see ouremergency vet visit cost guide.

When to See a Vet Instead of Self-Treating

OTC medications are appropriate for mild, temporary symptoms — occasional itching, mild stomach upset, or travel anxiety. But if symptoms persist beyond 48 hours, worsen, or are accompanied by lethargy, vomiting, diarrhea, or loss of appetite, stop self-treating and see your veterinarian. Chronic conditions like allergies, arthritis, and gastrointestinal disease require prescription medications at proper veterinary doses. For ongoing medication costs, see ourpet medication cost guide.